Vitamin D and Risk of Cardiovascular Disease.
نویسندگان
چکیده
Observational studies have mostly found a strong association of low plasma 25-hydroxyvitamin D (25(OH)D), usually used to measure vitamin D status, with increased risk of coronary heart disease, stroke, and cardiovascular death. However, recent Mendelian randomization studies and randomized intervention trials do not support a causal association of 25(OH)D or vitamin D supplementation with cardiovascular disease. This discrepancy has been ascribed to failures to account either for confounding or reverse causation in observational studies or for the nonlinear relationships in genetic studies and inappropriate recruiting of vitamin D replete individuals to vitamin D supplementation trials.
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عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 37 11 شماره
صفحات -
تاریخ انتشار 2017